Universal reference book for medicines
Name of the preparation: AVAXIM 80 (AVAXIM 80)

Active substance: hepatitis A vaccine

Type: Vaccine for the prevention of hepatitis A

Manufacturer: SANOFI PASTEUR (France)
Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
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PHARMACHOLOGIC EFFECT
The vaccine is a mixture of inactivated purified virions adsorbed on aluminum hydroxide.
Promotes the formation of immunity against the hepatitis A virus, causing the production of specific antibodies. The number of antibodies that appear after the use of the vaccine is practically the same as the number of antibodies to the hepatitis A virus in people who have undergone this disease. In most patients, antibodies circulate in the blood for at least 1 year after the initial course of vaccination.
INDICATIONS
Active prophylaxis in people with an increased risk of hepatitis A (including in an epidemic).

DOSING MODE
Individual.
A single dose depends on the age and is 0.5-1 ml IM in the deltoid region of the muscle. The vaccination schedule and the timing of the revaccination depend on the drug formulation used.
SIDE EFFECT
Perhaps: headache, malaise, fatigue, fever, nausea, loss of appetite;
hyperemia, compaction, swelling, tenderness at the injection site.
Very rare: anaphylactic and anaphylactoid reactions.

CONTRAINDICATIONS
Acute infectious and non-infectious diseases, exacerbations of chronic diseases, immunodeficiency states, malignant blood diseases and neoplasms, hypersensitivity to vaccine components, pregnancy, lactation (breastfeeding).

PREGNANCY AND LACTATION
In pregnancy, vaccination is not recommended and is only possible in cases of emergency.
If you need to use the drug during lactation, you should decide whether to stop breastfeeding.
APPLICATION FOR CHILDREN
In children, the vaccine should be used only in the form of dosage forms specially designed for them.

SPECIAL INSTRUCTIONS
They are used with caution in patients with thrombocytopenia and a tendency to hemorrhage, which is associated with an increased risk of developing a hematoma at the site of administration.
Do not inject in / in, sc, to / to. Patients on hemodialysis and patients with impaired immunity require the introduction of additional doses of the vaccine.
In children, the vaccine should be used only in the form of dosage forms specially designed for them.

Compliance with the recommended vaccine against hepatitis A should be strictly observed.

DRUG INTERACTION
The vaccine can be administered concomitantly with immunoglobulins, provided different parts of the body are used to inject the vaccine and immunoglobulins.
Since this vaccine is inactivated, combining it with other inactivated vaccines does not affect the effectiveness of vaccination when vaccines are introduced into various parts of the body (in particular, with a recombinant vaccine for the prevention of hepatitis B, typhoid vaccine, live vaccine for the prevention of yellow fever). The vaccine can be used for revaccination and in those cases when the previous vaccination was carried out by other inactivated vaccines for the prevention of hepatitis A.

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